& Paladin Power
Good day, 360!
Here are some of our top movers today. And don’t forget to join Jeff Bishop in Market Masters at 11AM EST today for his live Market Rundown in Bullseye Trades🔥. Be the best prepared trader on the Street!
FOCUS LIST🔎
PRTG – Up over 50% in the pre-market after announcing confirmatory preclinical results in Mesothelioma supporting first-in-human trial of PORT-7
CGON – Up over 40% in pre after best-in-disease durability data in BOND-003 cohort C and promising early signal in cohort P for Cretostimogene Grenadenorepvec at the American Urological Association annual meeting
GNPX – Up over 14% in pre after signing exclusive technology license agreement with New York University Langone Health for the treatment of Mesothelioma
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HOTLIST🔥
PRTG – Up over 50% in the pre-market after announcing confirmatory preclinical results in Mesothelioma supporting first-in-human trial of PORT-7
Portage Biotech Inc. (PRTG) is a clinical stage immune-oncology company that engages in the research and develops pharmaceutical and biotechnology products.
In the pre-market this morning, the company announcedconfirmatory preclinical efficacy data for PORT-7 (TT-4), a selective adenosine A2B receptor inhibitor.
The new data in a murine mesothelioma model demonstrated single agent activity for PORT-7 that was superior to treatment with single agent anti-PD1 antibody. Moreover, the combination of PORT-7 and anti-PD1 was superior to treatment with either anti-PD1 or PORT-7 alone. Immunohistochemistry of the tumors revealed the formation of tertiary lymphoid structures in the mice receiving the combination. This indication of a favorable immune response was accompanied by increases in immune effector cells in mice treated with the combination.
Portage is making preparations to commence a first-in-human clinical trial with PORT-7.
Shares of PRTG traded up over 50% in the pre-market in reaction to the news.
The $12.50 area acted as support in the pre-market and will be an important level to watch.
Above it, targets to the upside are $14.20, $15 and then the pre-market high at $15.35. Beyond that, $15.82, $20 and $23 come into play.
Below $12.50, targets to the downside are $12, $11, $10 and $9 and a gap fill at $8.45.
CGON – Up over 40% in pre after best-in-disease durability data in BOND-003 cohort C and promising early signal in cohort P for Cretostimogene Grenadenorepvec at the American Urological Association annual meeting
CG Oncology Inc. (CGON) is a late-stage clinical biopharmaceutical company that develops and commercializes backbone bladder-sparing therapeutics for patients with bladder cancer.
Over the weekend, the company announcedthat cretostimogene grenadenorepvec monotherapy data was presented at the Practice-Changing, Paradigm-Shifting Clinical Trials in Urology Plenary Session at the 2025 American Urological Association (AUA) Annual Meeting, in Las Vegas, Nevada.
Highlights include:
– Robust 24-month complete response rate of 42.3% by K-M for cretostimogene monotherapy in BOND-003 Cohort C –
– 58.3% of patients showed durable complete responses by K-M at 24 months –
– 97.3% of all treated patients remained free from progression to MIBC at 24 months–
– 91.6% of responders remained cystectomy-free at 24 months –
– No Grade 3 or greater treatment-related adverse events or deaths reported –
– Strong initial Cohort P data reported 90.5% high-grade recurrence-free survival at 3 and 9 months by K-M –
Shares of CGON traded up over 40% in the pre-market in reaction to the results.
The first target for bulls is the pre-market high at $32.40. Beyond that, $34, $36, $38 and $40 come into play.
Below $32.40, targets to the downside are $28, $27, $24 and then a gap fill at $22.37.
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GNPX – Up over 14% in pre after signing exclusive technology license agreement with New York University Langone Health for the treatment of Mesothelioma
Genprex Inc. (GNPX) is a clinical-stage gene therapy company that focuses on developing therapies for patients with cancer and diabetes.
In the pre-market this morning, the company announcedit has signed an exclusive patent license agreement with NYU Langone Health related to the drug candidate, Reqorsa® Gene Therapy (quaratusugene ozeplasmid).
The therapy is under investigation as a potential treatment for mesothelioma. The subject patent is co-owned by Genprex and NYU Langone Health, and the license provides Genprex with patent exclusivity.
Shares of GNPX traded up over 14% in the pre-market in reaction to the news.
The $0.30 area acted as support in the pre-market and will be an important level to watch.
Above it, targets to the upside are $0.32, $0.34, $0.39 and then the pre-market high at $0.40. Beyond that, $0.4366 and $0.53 come into play.
Below $0.30 targets to the downside are a gap to fill at $0.2846, $0.25 and then $0.22.
MARKET NEWS 📰
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