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Good day, 360!

Here are some of our top movers today. Don’t forget Jason’s NEW $2000 Small Account Journey starts today. Get in for a low as $197 🔥. Be the best prepared trader on the Street!

FOCUS LIST🔎

PPBT – Up over 70% in the pre-market after reporting positive final results from randomized Phase 2 study of CM24 in second line pancreatic cancer

SNTI – Up over 80% in pre after announcing positive initial clinical data in Phase 1 clinical trial of SENTI-202, a logic gated, selective CD33/FLT3- targeting CAR-NK Cell therapy for the treatment of relapsed/refractory Hematologic Malignancies Including AML

VMAR- Up over 14% in pre after announcing production partnership with Massimo Marine Announce for first commercial electric pontoon platform

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HOTLIST🔥

PPBT – Up over 70% in the pre-market after reporting positive final results from randomized Phase 2 study of CM24 in second line pancreatic cancer 

Purple Biotech Ltd. (PPBT) is a clinical-stage company that focuses on developing therapies to overcome tumor immune evasion and drug resistance for cancer patients in the United States.

In the pre-market this morning, the company reported positive final results from the randomized Phase 2 study of its lead oncology drug, CM24, a humanized monoclonal antibody that blocks CEACAM1, in patients with pancreatic ductal adenocarcinoma (PDAC).

Highlights include:

Final data demonstrate CM24 in combination with nivolumab and Nal-IRI/5FU/LV chemotherapy clear and consistent improvement across all efficacy endpoints

A biomarker enriched patient population analysis based on pretreatment ranges of serum CEACAM1 demonstrated significant improvement in the treatment arm over the control of 79% reduction in risk of death (HR 0.21, P = 0.04) with median OS improvement of 5.1 months and over 90% reduction in risk of progression or death (HR < 0.1, P = 0.003) with median PFS improvement of 2.9 months and improvement in the treatment arm over the control in ORR of 50% vs. 0%.

Phase 2b clinical study is planned in multiple selected indications, potentially targeting patients based on biomarkers  

Shares of PPBT traded up over 70% in the pre-market in reaction to the news.

The $4.90 area acted as support in the pre-market and will be an important level to watch.

Above it, targets to the upside are $5.60, $6, $6.50 and then the pre-market high at $6.70. Beyond that $7.80, $8.30 and $10 come into play. 

Below $4.90, targets to the downside are $4.65, $4, $3.81, $3.65 and then a gap fill at $3.36. 

SNTI – Up over 80% in pre after announcing positive initial clinical data in Phase 1 clinical trial of SENTI-202, a logic gated, selective CD33/FLT3- targeting CAR-NK Cell therapy for the treatment of relapsed/refractory Hematologic Malignancies Including AML

Senti Biosciences Inc. (SNTI) operates as a preclinical biotechnology company that develops next-generation cell and gene therapies engineered with its gene circuit platform technologies for various diseases.

In the pre-market this morning, the company announcedreported positive initial clinical data from a Phase 1 clinical trial of SENTI-202, a potential first-in-class Logic Gated off-the-shelf chimeric antigen receptor natural killer (“CAR-NK”) investigational cell therapy, for the treatment of relapsed/refractory (“R/R”) hematologic malignancies including acute myeloid leukemia (“AML”).

In addition, SNTI announced and oversubscribed $37.6 Million Private Placement Equity Financing.

Highlights include:

– 2 of 3 patients achieved MRD negative CR in the first dose level evaluated in the trial with a generally well-tolerated preliminary safety profile 

– Dose escalation is continuing with additional response and durability data expected in 2025 

Shares of SNTI traded up over 80% in the pre-market in reaction to the news.

The first target for bulls is the pre-market high at $6.34. Above it, targets to the upside are $7, $7.43 and $8.48.

Below $6.34, targets to the downside are $5.50, $4.50, $4, $3.70, $3, $2.50 and then a gap fill at $2.16.

sponsored by RYSE**

Amazon Bets Big on Smart Homes, You Can Too

VCs know how difficult it is to spot promising early investment opportunities. Even the Sharks from Shark Tank declined the offer to buy 10% of Ring for $700,000 – a decision they would regret when Amazon acquired Ring, turning the $700,000 into $10M!

RYSE is the smart-home brand poised to follow a similar trajectory. The founder pitched on Canada’s version of Shark Tank, Dragons’ Den and received two offers – it seems the Dragons’ learned from the Sharks’ mistakes. Don’t make the same mistake the sharks did.

VMAR- Up over 14% in pre after announcing production partnership with Massimo Marine Announce for first commercial electric pontoon platform

Vision Marine Technologies Inc. (VMAR) designs, develops, manufactures, sells, and rents electric boats in Canada, the United States, and internationally.

Over the weekend, the company announced a milestone partnership with Massimo Marine, the marine division of Massimo Group (MAMO). This collaboration will produce a fully integrated 30-foot electric pontoon platform designed for commercial and recreational markets. As part of Vision Marine’s strategic shift to offer complete electric boats directly to consumers, this partnership represents a key step in rapidly delivering high-quality electric marine products to market.

In 2023, pontoon boat sales reached 115,000 units, a 5% increase over 2022 (https://pontoonboatguy.com/). This robust market growth reflects the demand for versatile and family-friendly watercraft. 

Shares of VMAR traded up over 14% in the pre-market in reaction to the news.

The $2.40 area acted as support in the pre-market and will be an important level to watch. Above it, targets to the upside are $2.80, $3, $3.20, $3.40, $3.60 and then the pre-market high at $3.90.

Below $2.40, targets to the downside are $2.35 and then a gap to fill at $2.20. 

MARKET NEWS 📰

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